Hepatitis B :: Hep B DNA Flare Up During Tenofovir Treatment/viread
When I first began treatment with pegasys in january 2014, GGT was 60 (normal max is 35), ASAT 51 (normal max 35), ALAT 76 (normal 10-40), LDH/Bili/CK all within normal range. With pegasys, a few months later down the line, the values continued to go higher. At their highest, GGT 223, ASAT 116, ALAT 156, LDH 274, Bili/CK remained within normal range.
At the beginning of the treatment, Hep B ie/ml was 2400. Four months later, it became 2600. When I was shifted to tenofovir/Viread three or months after beginning treatment since pegasys wasn't solving the issue, the ASAT, ALAT, LDH came back down to normal levels quite fast. So I have been on viread ever since.
10 months after beginning treatment, Hep B ie/ml was down to 1800. In 2015, it was less than 150. Hep B Dna was undetected by May 2015. I get regular blood tests every three months since the start of the treatment.
Yesterday's blood test showed: ASAT 36 (normal max 35), ALAT 38 (normal 40, but having checked past blood tests, it seems in the last few months it has been gaining one or two points steadily so this is worrying me), LDH and Bili are normal. The bad news: Heb B DNA detected...and IE/ml was a whopping 3400!!!! More than when I started started treatment!
The first thing I was asked was whether I missed a dose of viread. Answer is no. However, I have had incidents where I did forget to take it on time, but it has never exceeded 5 hours (still, I know, it's a huge gap). Not a lot of times, but I find that I am beating myself over this now, as it may be the reason I am having a viral overload and maybe made the virus resistant to viread.
Since taking viread, I have experienced and continue to experience extreme muscle pain (I ended up in the hospital once when diclofenac failed me and I needed an extra morphine shot to get relief). I am continuously tired, some days it is a real struggle to move (feels like going through mud - heavy body, wanting to simply just crash on the floor). I have not had a pain free day in the last two years and worse, kidney stones! I am already prone to them, but I can't get over the suspicion that Viread has ensured I have a stone that needs to be taken out each year.
I've read that viread is one of the best treatment there is (hardly any side effects, probability of virus resistance low) so my latest blood test is worrying me no end. I am not due for another DNA test until 6 months later. I've also read that ASAT and ALAT values can increase and it's not necessarily liver related (I think my ongoing and increasing muscle pain is reflecting higher ASAT and ALAT values but who knows?!?).
My doctor says that as long as those values remain within normal range and not in the hundreds, it should be ok. But there is this unspoken thought that I am in deep trouble if the DNA continues to manifest and my liver enzyme values continue to increase. My liver scan in 2014 has me a point JUST before entering cirrhosis stage. I can't help but think I may have actually crossed that line already (the cassandra in me speaking) though I am assured that viread treatment tends to pull back the damage.
My question..Has anyone ever experienced a viral increase during the viread treatment, and if so, was it temporary, or was viread stopped? I am not sure how to read/interpret this ie/ml, but the fact that it has increased can't be good news at all.
Hepatitis B :: TDF (viread) Experiences Anyone?
After 1month of viread, my alt increased from 200 to 373.
Before:
Hbv DNA 170 million
As I said my Sgpt 200
Hbeag reactive
After 1 month
Hbv DNA 133,000
Hbeag reactive
Sgpt 373
My alt increasing is this normal?after 2 more months what will be next happen to my sgpt.please share with ur tdf experienced.
Hepatitis B :: 3 Months On Viread DNA Positive < 20 Iu/ml
I ve been on viread for 3 months. The latest hbv dna is positive <20 ıu/ml. Before viread I was on lamivudine and hbv dna was generally again positive <20 ıu/ml. I think it was 3 times undetectable at different times. Alt Ast normal afp normal. Do you think dna will be und next time? If it comes positive again what. treatment or evaluation can you recommend ? I also started to take vit d3 daily 10 days ago.
View 6 RepliesHepatitis B :: Viread Side Effects?
I have hepatitis b infection in the liver. I need your advise if I should take viread medication if I have osteopenia and my kidney is not the best? I am currently taking osteopenia pill. Please advise and help. Thanks a lot. I am worried about viread side effects on me. Another question is if I take the medicine, can I ever stop taking the medicine? Is it a life term medicine I have to take?
View 1 RepliesHepatitis B :: Viread Results After One Month
I want to know..if continue taking this..viread.my liver is going to serious damage?.my lab result before taking viread.
Hbv DNA - 170 million
Sgpt - 200
Hbeag - reactive
After 1 one month of taking tdf.
Hbv DNA - 100,000 something..
Hbeag - reactive
Sgpt - 337
Hepatitis B :: Is Viread A Safe Medicine?
My Doctor prescribed a viread/ tenofavir.shall i take it.Is it a safe antiviral drug.What can i expect as a side effects?
View 2 RepliesHepatitis B :: Viread Generic Or Brand
My doctor let me have Viread. I checked online at pharmacy checker. Tenofovir Disoproxil Fumarate Tablet and Viread Tablet, are they the same in treatment wise? I went to CVS store, it cost 1000 USD to 30/300mg for Viread Tablet. is it too expensive? The staff there told me generic tablet is not available. But why I see it online as I said earlier?
What happens if I take brand and then switch to generic like a year later? Will the generic medicine do the same?
Hepatitis B :: Viread And Hair Loss
So I've been taking viread before bed for the last 4 years. My hair has been receding and falling out throughout those years. It is now getting really aggressive and noticeable. I stopped taking viread for a month to see if it would reverse and sure enough it did. It came back full and thick. Yesterday I took viread again and half of what came back began falling out. Does anyone have any tips or suggestions? I'm still young and my parents have good hair. What can I do to stop or prevent? I tried taking biotin but it seems its not enough
View 16 RepliesHepatitis B :: Nails Discoloration After Starting Viread
Has anyone experience nail discoloration after starting viread?
View 11 RepliesHepatitis B :: ALT Increase After Stopped VIREAD 3 Weeks
I just had my second child 7 weeks ago. I stopped taking VIREAD FOR 3 weeks after gave birth because of breastfeeding. But ALT was increased to 53. Then I continue to take VIREAD but now the ALT is still 53. I remember this medicine can control liver function very quick when I started to take it years ago. is it possible the medicine doesn't work on me anymore? anybody can explain?
View 1 RepliesHepatitis B :: Viral Load Still Around 200 IU After 3 Years Of Viread
I have been on Viread for three years and my viral load never goes undetectable. The viral load went down in the past two years. However, it has been up and down in the range of 100 to 300 IU in the past year. It seems that it will never go down to undetectable. The test for mutation failed three times because of very low viral load. Am I non-responder to Viread? Should I switch to another treatment? Should I be concerned?
View 13 RepliesHepatitis B :: Gilead's Hep B Drug As Effective As Viread But Safer
There is a link about tenofovir alafenamide (TAF).
View 7 RepliesHepatitis C: Post Treatment :: Sofosbuvir+Daclatasvir Treatment Relapse
I'm looking for advice. My 60 year old father (who has had HCV for more than 10 years; previously treated with Interferon but bad side effects) finished his 12 week Sofosbuvir+Daclatasvir (considered same as Harvoni) treatment a month ago. Already first tests after 2 weeks showed virus was Undetected, but yesterday he received his most recent results and he has a relapse of the virus. He is genotype 1, fibroscan result 4 (close to final stage). He is based in Poland and I'm not sure if our doctors are fully informed of the new generation medications and HCV itself.
Is anyone able to give us any advice? We are pretty desperate and my dad is just so depressed as he thought he finally got rid of the virus (he got infected while on an operation in a public hospital) and now it is back...
Are there any specialists that you are aware of I could possibly get in contact with?
Hepatitis C Post Treatment :: Relapse After Harvoni Treatment?
Does anyone here relapse after harvoni treatment?
View 3 RepliesHepatitis C Post Treatment :: CRP (c-reactive Protein)
My sister in law, a very good doctor who has always given me sensible advice when I have asked, suggested I get my CRP checked. CRP is apparently a marker for inflammation in the body, although lupus and rheumatoid arthritis do not always trigger it.
I know I sound like a broken record, but I really think a lot of post-interferon syndrome can be explained by body-wide inflammation - chronic fatigue arises from an inflamed brain; psoriasis is inflamed skin; arthritis is inflamed joints; fibromyalgia is inflamed muscle tissue; vasculitis is inflamed blood vessels, etc.
Our immune systems were amped up by the drugs, and they never settled down again quite right. The drugs induce autoimmune disorders that can effect every system of our body.
If I eat bagels and cream cheese (I love bagels and cream cheese) for two or three days in a row, and throw in a pizza, all my inflammatory symptoms get worse, including depression and fatigue. My ankles swell. My psoriasis gets worse. My joints start aching worse. My fingers start trembling and twitching spastically. I had nothing like this before treatment.
So anyway, if anyone cares to follow this theory, it means eating a non-inflammatory diet - no pizza, no fast food, skip the sugar, read In Defense of Food. The more you want to live, the better you will eat. If anyone cares to follow this theory and is having their blood drawn anyway, be sure and get CRP checked. My sis-in-law says it's very inexpensive test. I'd love to hear of any correlation or thoughts on this subject.
Hepatitis C :: Relapse After Daclatasvir And Sofosbuvir Treatment
I have just found out that my father who has finished his 12 weeks treatment (Sofosbuvir + Daclatasvir) about a month ago has had the virus relapse. It was undetectable in all previous tests, but the recent test showed it. I was wondering if anyone can point me to the right sources, perhaps specialists and experts we could contact as in Poland (where we live) there doesn't seem to be enough information. We are not sure what to do next... He has had this horrible virus for more than 10 years, we were so happy to have cured it! But refuse to lose hope and want to keep fighting!
View 4 RepliesHepatitis C :: Unsuccessful Treatment? Feedback Reviews?
I am currently on Harvoni for my Hep C and I wanted to ask has anyone had the virus return or a unsuccessful treatment?
View 2 RepliesHepatitis C :: Harvoni - SVR And Side Effects During Or After Treatment?
I'm finishing up my last two weeks of treatment on Harvoni and wanted to know some feedback from people about there current health situation such as achievements of SVR,and side effects during or after treatment?
View 6 RepliesHepatitis C :: How Long Sovaldi / Riba For Complete Treatment?
Its been Since Tuesday PM since I finished my 12 weeks and I still feel like I am on it.
View 3 Replies